Alice (Milla Jovovich
), one of only two survivors of the contained biochemical disaster in the first Resident Evil
, has been subjected to biogenetic experimentation by the vast Umbrella Corporation and becomes genetically altered, with super-human strengths, senses and dexterity. These skills and more will be needed if anyone is to remain alive. Alice is joined by Jill Valentine (Sienna Guillory
), a recently demoted member of Umbrella Corp's elite Special Tactics and Rescue Services (S.T.A.R.S.), Terri Morales (Sandrine Holt
), Carlos Olivera (Oded Fehr
), L.J. (Mike Epps
), and Nicholai (Zack Ward
) who must survive and escape what is quickly becoming a City of the Dead. To reach their goal, they will need to battle their way through the relentless onslaught of the ravenous undead, as well as Umbrella forces and terrifying bioengineered weapons, the most deadly of which is the colossal, heavily armed assassin, Nemesis.