Kate Collins (Zooey Deschanel
), struggling through an awkward first year at college, returns home upon the death of her grandfather. At school, Kate might not fit in, but at home, she is quickly surrounded by a disruptive group of people even weirder than she is: her family.
First, there's her father, Daniel (Hank Azaria), once child star, now in "adult" films. Then there's tightly wound Aunt Lucy (Kelly Preston) who has waited till the last minute to announce her wedding to life partner Judy (Famke Janssen), and wildly inappropriate Uncle Skip (Ray Romano) with his obnoxious twin boys. And last but not least, there's pushy Aunt Alice (Debra Winger) whose brash approach to marriage, motherhood and casseroles is unsettling to all concerned.
When her grandmother (Piper Laurie) entrusts her with the task of delivering the eulogy at the funeral, Kate turns to her relatives for help. She quickly comes to realize that her own fond memories of Grandpa Collins (Rip Torn) are not shared by his children.