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Years after escaping custody, the brilliant but psychotic Dr. Hannibal Lecter (Hopkins) settles in Italy and becomes the curator of an art museum in Florence, even learning to curb his appetite for human flesh.

Back in the States, FBI agent Clarice Starling (Moore) has been discredited by the bureau and her nights have been haunted by dreams of her past conversations with Lecter.

Mason Verger, a twisted pedophile whose encounter with Lecter left him disfigured and paralyzed, places a bounty on Lecter's head. When Clarice gets word, she goes in search of Lecter to warn him and unwittingly becomes a pawn in Verger's plans for revenge.


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