In this action-horror flick from director Robert Rodriguez and screenwriter Quentin Tarantino, Tarantino stars with George Clooney as a pair of bad-to-the-bone brothers named Seth and Richie Gecko. After a string of robberies that left a river of blood in the Geckos' wake, the sadistic siblings head to Mexico to live the good life.
To get over the border, they kidnap Jacob Fuller, a widowed preacher played by Harvey Keitel, and his two children, Kate (Juliette Lewis) and Scott (Ernest Liu). Once south of the border, the quintet park their RV at a rough-and-tumble trucker bar called The Titty Twister, where Seth and Richie are supposed to meet a local thug.
After a couple of drinks, they realize that they're not in a typical bar, as the entire place begins to teem with vicious, blood-sucking vampires. With the odds stacked greatly against them, the Fullers and Geckos team together in hopes of defeating the creatures of the night.