Irene Trent (Barbara Stanwyck) was married to the inventor Howard (Hayden Roarke) before the blind electronics genius blows himself up following an argument between the couple. Irene leaves after the arguments only to learn of her husband's demise later.
When Irene has reoccurring dreams of a faceless lover, she confides in her friend and attorney Barry Moreland (Robert Taylor) of her vision. She also tells him that Howard had accused her of marital infidelity and had her trailed by a private detective. William Castle directed the suspenseful thriller written by Psycho author Robert Bloch.
Taylor and Stanwyck appear in their first film together in 27 years. The two were married from 1939 to 1951 and appeared in two films before their marriage. Their mutual respect as friends and performers is evident in The Night Walker.