Jack Bishop lives the life of every man's dream with his beautiful wife, Amaya, and a happy, healthy daughter, Toby. When Toby goes missing, Jack knows his past has come back to haunt him. He also knows the only way he can find her is to use the powers of his long forgotten faith, La Santa Muerte, protectors of the sinner, the worshippers of the dead.
Accompanied by the insecure newly-appointed sheriff and a pair of wary FBI agents, Jack's search takes him deep into his past, to a psychic who visualizes Jack's secret in terrifying detail, to the squalid barrios and seediest brothels in Mexico City's underbelly.
But, the power of the La Santa Muerte is stronger then he ever imagined, as it reaches out to touch his family and reveals an even darker and unexpected web of lies and deceit.