An ancient urn chained to a coffin is unearted by chance by some men at work along the road bordering the Viterbo's cemetery. The urn contains an age-old tunic and some objects belonging to Mater Lacrimarum, the Third Mother.
The only survivor of the Three Mothers - three powerful witches who had been shedding blood and terror for aeons - Mater Lacrimarum has been hiding in Rome for centuries and her awakening triggers a chain of mysterious and terrible events: the Evil is back to cast its dark shadow over the city.
Sarah Mandy, a young student of restoration, co-worker and love interest of Michael Pierce, the curator of the Museum of Ancient Art of Rome, is involved in the escalating and increasingly frantic episodes of violence.
Sarah tries to run away but she cannot: the Third Mother is looking for her and Sarah is not aware of the fact that her mother Elisa Mandy was a powerful white witch brutally killed by Mater Suspiriorum, the witch from Fryeburg.
Helped by the spirit of her mother, by an eminent esoterism academic, Guglielmo De Witt, and by the Chief Constable Marchi, Sarah realizes that she has no way out and that she must face the impending threat