L'Amour en Fuite (Love on the Run) is presented in flashbacks from the previous four movies as Antoine Doinel (Jean-Pierre Léaud) meets up with people from his past. As the fifth and final film in the series, Antoine is over 30 years old and meets with his wife, Christine (Claude Jade), to sign the papers for their divorce.
As it is the first no-fault divorce of its kind in France, the press surrounds them. In the crowd is also Antoine's past love, Colette (Marie-France Pisier), who is now a lawyer and in love with Xaiver the Librarian (Daniel Mesguich).
Antoine is in love with Sabine (Dorothée), but she breaks things off when he ditches her to go see his son at the train station. While he is there, he impulsively joins Colette on a train ride where they recall their past and go through his recent autobiographical novel.
Finally, Monsieur Lucien (Julien Bertheau) also re-enters Antoine's life and they visit his mother's grave at Montmartre.