I.K.U. starts where Blade Runner ends. It is the year 20XX, and the Tyrell Corporation is now the Genom Corporation, a multinational enterprise that manufactures 'replicants' known as GenXXX IKU Coders.
Rachael and Deckard are now Reiko and Dizzy, and the story is picked up in the elevator, where Dizzy, a Genom salary man, is initiating Reiko's OS IKU 3.0 sex hard drive. Reiko is then sent out into the world to collect orgasm data for Genom, is eventually infiltrated by BioLink's TokyoRose virus, and experiences a system breakdown.
Mash, a retired IKU Coder, comes to the rescue by teaching Reiko masturbation, showing her the secret reset button. The restarted Reiko catches up with Hustler Akira in a Japanese fish restaurant, where executing all sex positions fulfills the data collection.
Dizzy downloads Reiko's XXX data, and with it Genom codes IKU databases on the Net and sells IKU chips in vending machines. Now everyone can have a Genom-coded pleasure trip!