Brigitte Fitzgerald (Emily Perkins
) does not wish to transform into the hideous werewolf her sister Ginger (Katharine Isabelle
) became in the original Ginger Snaps
. When Ginger cut both her and her sister’s hands, then clasped their wounds together, Brigitte contracted her sister’s affliction. Brigitte has to take an antidote via injections to keep from transforming into a beast, but when she takes too much, she collapses and comes to in a rehabilitation clinic. Found on the street, Brigitte was mistaken for a junkie and taken to the lock down facility. Without regular doses of the antidote, her transformation begins to accelerate, and she attracts the attention of Ghost (Tatiana Maslany
), an odd 14-year-old at the clinic, as well as the beast, who is drawn by the attraction of a female that is turning into a creature like him.