Handsome young Washington attorney Louie Jeffries (Chris McDonald) has it all: a promising career, a beautiful wife, and a baby on the way. But after discovering a local judge is in cahoots with the Mob, Louie bites it in a car crash and finds himself in Heaven.
Unsatisfied with the customer service he's receiving, Louie jumps the gun and gets himself reincarnated -- before being administered the magic injection that will remove his memories of his former life.
For the next quarter-century, Louie's museum curator wife, Corinne (Cybill Shepherd), remains true to her husband's memory, ignoring the frustrated devotion of Louie's best friend, Philip Train (Ryan O'Neal). Meanwhile, Louie's soul grows up in the body of Alex Finch (Robert Downey Jr.), an aspiring journalist.
Alex's memories of his life as Louie return after he becomes romantically involved with Miranda (Mary Stuart Masterson) -- the daughter he never got to meet. Soon, Alex/Louie is romancing his wife, spurning his daughter's advances, and frustrating Philip's attempts finally to woo Corinne.
Written by Mystic Pizza scribes Perry and Randy Howze and directed by Emile Ardolino of Dirty Dancing fame, Chances Are didn't score as well at the box office as those earlier comedies. Its soundtrack, however, generated the hit Peter Cetera and Cher ballad After All.